GST – Genetics of Detoxification Enzymes

Product detailed description

The GST genetic test identifies inherited variants in genes involved in the body's natural detoxification processes. These genes influence the activity of enzymes called glutathione S-transferases (GSTs), which help process certain potentially harmful substances, metabolic byproducts, and compounds produced during oxidative stress.

Glutathione S-transferase enzymes play an important role in the body's natural cellular defense mechanisms. They participate in phase II biotransformation, helping attach glutathione to certain chemical compounds. This process can facilitate further processing and elimination of these substances from the body. GST enzymes are active in the liver and many other tissues.

Certain GST genetic variants may affect the activity of individual detoxification enzymes. Commonly studied genes include GSTM1, GSTT1, and GSTP1. Variations in these genes may contribute to individual differences in the metabolism of certain substances and cellular protective mechanisms.

GST genetic testing provides insights into inherited genetic factors related to the metabolism of selected chemicals and the protection of cells against oxidative damage.

What does the test detect?

• The presence of selected genetic variants in GST genes.

• Genetic factors associated with glutathione S-transferase enzyme activity.

• Inherited differences that may influence the metabolism of certain foreign compounds and metabolic byproducts.

• Genetic characteristics related to cellular protection against oxidative stress.

The test does not measure current toxin levels or the body's overall ability to eliminate harmful substances. Detoxification is a complex process influenced by numerous enzymes, health conditions, lifestyle, and environmental factors. Genetic results alone cannot reliably predict the risk of developing a specific disease.